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Case Reports
. 2014 May;62(5):638-41.
doi: 10.4103/0301-4738.129786.

A new rosette in retinoblastoma

Dipankar Das  1 , Kasturi Bhattacharjee, Sumita Sarma Barthakur, Prerana Sushil Tahiliani, Panna Deka, Harsha Bhattacharjee, Apurba Deka, Rajashree Paul
Affiliations
Case Reports

A new rosette in retinoblastoma

Dipankar Das et al. Indian J Ophthalmol. 2014 May.

Abstract

Retinoblastoma, the most common primary malignant intraocular tumor of childhood is a great success story in pediatric and ocular oncology. Pathology of retinoblastoma is important to guide the treatment modalities. Differentiated retinoblastoma is commonly seen in younger age group. Since a hundred years, we have been observing two typical true rosettes in retinoblastoma in the form of Flexner-Wintersteiner (FW) and Homer Wright (HW) rosettes and in many occasions pseudorosettes have been documented. In the present case report, a third new type of rosette was identified in a differentiated retinoblastoma which had an unusual anterior segment involvement.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Gross documentation of retinoblastoma specimen. Surface calcification can be noted
Figure 2
Figure 2
Basophilic tumor cells infiltrating anterior chamber and endothelium of cornea (hematoxylin and esoin (H and E, ×100)
Figure 3
Figure 3
Flexner-Wintersteiner (FW) rosette with clear lumen at the center (H and E, ×400)
Figure 4
Figure 4
Homer Wright (HW) rosette with central tangle of neural filament. There is no clear lumen at the center (H and E, ×400)
Figure 5
Figure 5
Newly observed rosette with basophilic cuboidal cells occupying the center of lumen. Cytoplasmic extensions of the cells can be noted. (H and E, × 400)
Figure 6
Figure 6
One of the newly observed rosettes stained with alcian blue (HR-AMP). Lumen was stained (×400). HR-AMP = hyaluronidaseresistant acid mucopolysaccharides
Figure 7
Figure 7
Alcian blue (HR-AMP) stained central lumen of FW rosette in same slide as control (×400)
Figure 8
Figure 8
Necrosis and calcification (H and E, ×200)
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