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Editorial
. 2014 Aug;8(6):583-5.
doi: 10.1586/17474124.2014.911659. Epub 2014 May 31.

Does stress induce bowel dysfunction?

Yu-Ming Chang  1 , Mohamad El-Zaatari, John Y Kao
Affiliations
Editorial

Does stress induce bowel dysfunction?

Yu-Ming Chang et al. Expert Rev Gastroenterol Hepatol. 2014 Aug.

Abstract

Psychological stress is known to induce somatic symptoms. Classically, many gut physiological responses to stress are mediated by the hypothalamus-pituitary-adrenal axis. There is, however, a growing body of evidence of stress-induced corticotrophin-releasing factor (CRF) release causing bowel dysfunction through multiple pathways, either through the HPA axis, the autonomic nervous systems, or directly on the bowel itself. In addition, recent findings of CRF influencing the composition of gut microbiota lend support for the use of probiotics, antibiotics, and other microbiota-altering agents as potential therapeutic measures in stress-induced bowel dysfunction.

Keywords: NLRP6; bowel dysfunction; irritable bowel syndrome; microbiota; stress.

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Conflict of interest statement

Financial & competing interests disclosure

The authors acknowledge grant support from NIH T32DK094775. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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References

    1. Thompson WG. The irritable colon. CMAJ. 1974;111(11):1236, 1241–1234. - PMC - PubMed
    1. Martinez V, Wang L, Rivier JE, et al. Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J Pharmacol Exp Ther. 2002;301(2):611–17. - PubMed
    1. Kihara N, Fujimura M, Yamamoto I, et al. Effects of central and peripheral urocortin on fed and fasted gastroduodenal motor activity in conscious rats. Am J Physiol Gastrointest Liver Physiol. 2001;280(3):G406–19. - PubMed
    1. Czimmer J, Million M, Tache Y. Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. Am J Physiol Gastrointest Liver Physiol. 2006;290(3):G511–18. - PubMed
    1. Soderholm JD, Yates DA, Gareau MG, et al. Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am J Physiol Gastrointest Liver Physiol. 2002;283(6):G1257–63. - PubMed

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