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Review
. 2014 Aug;19(8):1264-9.
doi: 10.1016/j.drudis.2014.05.015. Epub 2014 Jun 2.

miRNAs in PAH: biomarker, therapeutic target or both?

Jolyane Meloche  1 , Aude Pflieger  1 , Mylène Vaillancourt  1 , Colin Graydon  1 , Steeve Provencher  1 , Sébastien Bonnet  2
Affiliations
Review

miRNAs in PAH: biomarker, therapeutic target or both?

Jolyane Meloche et al. Drug Discov Today. 2014 Aug.

Abstract

Pulmonary arterial hypertension (PAH) is characterized by progressive increase in pulmonary vascular resistance leading to right ventricular hypertrophy and failure. There is a need to find new biomarkers to detect PAH at its early stages and also for new, more effective treatments for this disease. miRNAs have emerged as key players in cardiovascular diseases and cancer development and progression and, more recently, in PAH pathogenesis. In this review, we focus on the potential of miRNAs as biomarkers and new therapeutic targets for PAH.

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