Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?
- PMID: 24882134
- DOI: 10.1016/j.anclin.2014.02.004
Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?
Abstract
In a growing outpatient surgical population, postdischarge nausea and vomiting (PDNV) is unfortunately a common and costly anesthetic complication. Identification of risk factors for both postoperative nausea and vomiting and PDNV is the hallmark of prevention and management. New pharmacologic interventions with extended duration of action, including palonosetron and aprepritant, may prove to be more efficacious.
Keywords: Aprepitant; Casopitant; Nausea; Palonosetron; Postdischarge; Postoperative; Rolapitant; Vomiting.
Copyright © 2014 Elsevier Inc. All rights reserved.
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