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Review
. 2014 Jun;32(2):505-16.
doi: 10.1016/j.anclin.2014.02.004. Epub 2014 Apr 18.

Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?

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Review

Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?

M Stephen Melton et al. Anesthesiol Clin. 2014 Jun.

Abstract

In a growing outpatient surgical population, postdischarge nausea and vomiting (PDNV) is unfortunately a common and costly anesthetic complication. Identification of risk factors for both postoperative nausea and vomiting and PDNV is the hallmark of prevention and management. New pharmacologic interventions with extended duration of action, including palonosetron and aprepritant, may prove to be more efficacious.

Keywords: Aprepitant; Casopitant; Nausea; Palonosetron; Postdischarge; Postoperative; Rolapitant; Vomiting.

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