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Review
. 2014 Jul;23(3):567-77.
doi: 10.1016/j.soc.2014.03.003.

Basal-like and triple-negative breast cancers: searching for positives among many negatives

Prasanna Alluri  1 , Lisa A Newman  2
Affiliations
Review

Basal-like and triple-negative breast cancers: searching for positives among many negatives

Prasanna Alluri et al. Surg Oncol Clin N Am. 2014 Jul.

Erratum in

  • Surg Oncol Clin N Am. 2014 Oct;23(4):xv

Abstract

Triple-negative breast cancers (TNBC) are defined by their failure to express the estrogen receptor, progesterone receptor, and HER2/neu protein markers. This basic feature is clinically relevant because it indicates that these cancers cannot be managed with endocrine or anti-HER2 systemic therapies. Furthermore, most TNBC cases are also characterized as being of the genetically defined basal subtype, which is an inherently and biologically more aggressive pattern of disease. The two terms, however, are not synonymous, and some TNBC cases are prognostically more favorable. TNBC differs from non-TNBC in risk-factor profile, pattern, and rate of metastatic spread.

Keywords: Basal breast cancer; Breast cancer subtypes; Triple-negative breast cancer.

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References

    1. Brenton JD, Carey LA, Ahmed AA, Caldas C. Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol. 2005 Oct;23(29):7350–7360. - PubMed
    1. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000 Aug 17;406(6797):747–752. - PubMed
    1. Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med. 2010 Nov;363(20):1938–1948. - PubMed
    1. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869–10874. - PMC - PubMed
    1. Bertucci F, Finetti P, Cervera N, et al. How basal are triple-negative breast cancers? Int J Cancer. 2008 Jul;123(1):236–240. - PubMed

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