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. 2014 Jun 1;37(6):1127-42.
doi: 10.5665/sleep.3776.

Dissociating effects of global SWS disruption and healthy aging on waking performance and daytime sleepiness

John A Groeger  1 , Neil Stanley  2 , Stephen Deacon  3 , Derk-Jan Dijk  2
Affiliations

Dissociating effects of global SWS disruption and healthy aging on waking performance and daytime sleepiness

John A Groeger et al. Sleep. .

Abstract

Study objective: To contrast the effects of slow wave sleep (SWS) disruption and age on daytime functioning.

Design: Daytime functioning was contrasted in three age cohorts, across two parallel 4-night randomized groups (baseline, two nights of SWS disruption or control, recovery sleep).

Setting: Sleep research laboratory.

Participants: 44 healthy young (20-30 y), 35 middle-aged (40-55 y), and 31 older (66-83 y) men and women.

Interventions: Acoustic stimulation contingent on appearance of slow waves.

Measurements and results: Cognitive performance was assessed before sleep latency tests at five daily time-points. SWS disruption resulted in less positive affect, slower or impaired information processing and sustained attention, less precise motor control, and erroneous implementation, rather than inhibition, of well-practiced actions. These performance impairments had far smaller effect sizes than the increase in daytime sleepiness and differed from baseline to the same extent for each age group. At baseline, younger participants performed better than older participants across many cognitive domains, with largest effects on executive function, response time, sustained attention, and motor control. At baseline, the young were sleepier than other age groups.

Conclusions: SWS has been considered a potential mediator of age-related decline in performance, although the effects of SWS disruption on daytime functioning have not been quantified across different cognitive domains nor directly compared to age-related changes in performance. The data imply that two nights of SWS disruption primarily leads to an increase in sleepiness with minor effects on other aspects of daytime functioning, which are different from the substantial effects of age.

Keywords: aging; cognition; daytime functioning; sleep; slow wave sleep.

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Figures

Figure 1
Figure 1
Cohen's d effect sizes of daytime performance impairment across cognitive domains following two nights of SWS disruption. The only simple performance improvement from baseline (GNTCOR), is shown with a diagonal filled bar. Significance of planned contrasts is shown with (*) and without (+) correction for False Discovery Rate.
Figure 2
Figure 2
Cohen's d effect sizes of age-related decline in daytime performance across cognitive domains. Lower subjective and objective sleepiness in older participants are shown with diagonal filled bars. Significance of planned contrasts is shown with (*) and without (+) correction for False Discovery Rate.
Figure 3
Figure 3
Contrasting effect sizes of age-related decline and SWS disruption across cognitive domains.
See this image and copyright information in PMC

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