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. 2014 May 14:9:37.
doi: 10.1186/1749-7922-9-37. eCollection 2014.

Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

Massimo Sartelli  1 , Fausto Catena  2 , Luca Ansaloni  3 , Federico Coccolini  3 , Davide Corbella  4 , Ernest E Moore  5 , Mark Malangoni  6 , George Velmahos  7 , Raul Coimbra  8 , Kaoru Koike  9 , Ari Leppaniemi  10 , Walter Biffl  5 , Zsolt Balogh  11 , Cino Bendinelli  11 , Sanjay Gupta  12 , Yoram Kluger  13 , Ferdinando Agresta  14 , Salomone Di Saverio  15 , Gregorio Tugnoli  15 , Elio Jovine  16 , Carlos A Ordonez  17 , James F Whelan  18 , Gustavo P Fraga  19 , Carlos Augusto Gomes  20 , Gerson Alves Pereira  21 , Kuo-Ching Yuan  22 , Miklosh Bala  23 , Miroslav P Peev  7 , Offir Ben-Ishay  13 , Yunfeng Cui  24 , Sanjay Marwah  25 , Sanoop Zachariah  26 , Imtiaz Wani  27 , Muthukumaran Rangarajan  28 , Boris Sakakushev  29 , Victor Kong  30 , Adamu Ahmed  31 , Ashraf Abbas  32 , Ricardo Alessandro Teixeira Gonsaga  33 , Gianluca Guercioni  34 , Nereo Vettoretto  35 , Elia Poiasina  3 , Rafael Díaz-Nieto  36 , Damien Massalou  37 , Matej Skrovina  38 , Ihor Gerych  39 , Goran Augustin  40 , Jakub Kenig  41 , Vladimir Khokha  42 , Cristian Tranà  43 , Kenneth Yuh Yen Kok  44 , Alain Chichom Mefire  45 , Jae Gil Lee  46 , Suk-Kyung Hong  47 , Helmut Alfredo Segovia Lohse  48 , Wagih Ghnnam  32 , Alfredo Verni  49 , Varut Lohsiriwat  50 , Boonying Siribumrungwong  51 , Tamer El Zalabany  52 , Alberto Tavares  53 , Gianluca Baiocchi  54 , Koray Das  55 , Julien Jarry  56 , Maurice Zida  57 , Norio Sato  9 , Kiyoshi Murata  58 , Tomohisa Shoko  59 , Takayuki Irahara  60 , Ahmed O Hamedelneel  61 , Noel Naidoo  62 , Abdul Rashid Kayode Adesunkanmi  63 , Yoshiro Kobe  64 , Wataru Ishii  65 , Kazuyuki Oka  66 , Yoshimitsu Izawa  67 , Hytham Hamid  68 , Iqbal Khan  68 , Ak Attri  13 , Rajeev Sharma  13 , Juan Sanjuan  17 , Marisol Badiel  17 , Rita Barnabé  16
Affiliations

Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

Massimo Sartelli et al. World J Emerg Surg. .

Abstract

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

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Figures

Figure 1
Figure 1
Participating centers for each continent.
See this image and copyright information in PMC

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