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Case Reports
. 2014 Aug;6(4):302-4.
doi: 10.14740/jocmr1850w. Epub 2014 May 22.

Acute acalculous cholecystitis in patients with clear cell renal cell carcinoma treated with sunitinib: report of two cases

Nobuki Furubayashi  1 , Takahito Negishi  1 , Yu Hirata  1 , Kenichi Taguchi  2 , Motonobu Nakamura  1
Affiliations
Case Reports

Acute acalculous cholecystitis in patients with clear cell renal cell carcinoma treated with sunitinib: report of two cases

Nobuki Furubayashi et al. J Clin Med Res. 2014 Aug.

Abstract

Although sunitinib is associated with a variety of adverse events, cases of sunitinib-related acute cholecystitis have rarely been reported. We herein report two cases of sunitinib-related acute acalculous cholecystitis in patients with clear cell renal cell carcinoma. In both cases, the gallbladder was surgically removed because it was difficult to improve the patient's condition with the cessation of sunitinib and non-surgical treatment only. Attention must be paid to the possibility of sunitinib-related acute cholecystitis, which, although uncommon, can be life-threatening.

Keywords: Acute acalculous cholecystitis; Adverse event; Cholecystectomy; Clear cell renal cell carcinoma; Sunitinib.

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Figures

Figure 1
Figure 1
Abdominal computed tomography showed a tense and dilated gallbladder with surrounding fluid collection without gallbladder stones or emphysematous changes.
Figure 2
Figure 2
Abdominal ultrasonography revealed thickening of the gallbladder wall without gallbladder stones or emphysematous changes.
Figure 3
Figure 3
Thickened gallbladder wall in transmural lymphoeosinophilic inflammation with hemorrhage and necrotic change.
See this image and copyright information in PMC

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