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Randomized Controlled Trial
. 2014:2014:686287.
doi: 10.1155/2014/686287. Epub 2014 May 6.

Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block?

Ahmet Can Senel  1 , Ozlem Ukinc  1 , Alper Timurkaynak  2
Affiliations
Randomized Controlled Trial

Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block?

Ahmet Can Senel et al. Biomed Res Int. 2014.

Abstract

Background and objectives: A prospective, randomized, controlled, double-blind clinical trial to assess the effect of tramadol and ketamine, 50 mg, added to ropivacaine in brachial plexus anesthesia.

Methods: Thirty-six ASA physical statuses I and II patients, between 18 and 60 years of age, scheduled for forearm and hand surgery under axillary brachial plexus block, were allocated to 3 groups. Group R received 0.375% ropivacaine in 40 mL, group RT received 0.375% ropivacaine in 40 mL with 50 mg tramadol, and group RK received 0.375% ropivacaine in 40 mL with 50 mg ketamine for axillary brachial plexus block. The onset times and the duration of sensory and motor blocks, duration of analgesia, hemodynamic parameters, and adverse events (nausea, vomiting, and feeling uncomfortable) were recorded.

Results: The onset time of sensorial block was the fastest in ropivacaine + tramadol group. Duration of sensorial and motor block was the shortest in the ropivacaine + tramadol group. Duration of analgesia was significantly longer in ropivacaine + tramadol group.

Conclusion: We conclude that when added to brachial plexus analgesia at a dose of 50 mg, tramadol extends the onset and duration time of the block and improves the quality of postoperative analgesia without any side effects.

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References

    1. Tverskoy M, Braslavsky A, Mazor A, Ferman R, Kissin I. The peripheral effect of fentanyl on postoperative pain. Anesthesia & Analgesia. 1998;87(5):1121–1124. - PubMed
    1. Bazin JE, Massoni C, Bruelle P, Fenies V, Groslier D, Schoeffler P. The addition of opioids to local anaesthetics in brachial plexus block: the comparative effects of morphine, buprenorphine and sufentanil. Anaesthesia. 1997;52(9):858–862. - PubMed
    1. Wajima Z, Shitara T, Nakajima Y, et al. Continuous brachial plexus infusion of butorphanol-mepivacaine mixtures for analgesia after upper extremity surgery. British Journal of Anaesthesia. 1997;78(1):83–85. - PubMed
    1. Karakaya D, Büyükgöz F, Barş S, Güldouş F, Tür A. Addition of fentanyl to bupivacaine prolongs anesthesia and analgesia in axillary brachial plexus block. Regional Anesthesia and Pain Medicine. 2001;26(5):434–438. - PubMed
    1. Mezzatesta JP, Scott DA, Schweitzer SA, Selander DE. Continuous axillary brachial plexus block for postoperative pain relief intermittent bolus versus continuous infusion. Regional Anesthesia. 1997;22(4):357–362. - PubMed

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