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. 2014 May 18:14:67.
doi: 10.1186/1471-2415-14-67.

Role of inflammation in previously untreated macular edema with branch retinal vein occlusion

Hidetaka Noma  1 , Tatsuya Mimura, Katsunori Shimada
Affiliations

Role of inflammation in previously untreated macular edema with branch retinal vein occlusion

Hidetaka Noma et al. BMC Ophthalmol. .

Abstract

Background: The association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, soluble intercellular adhesion molecule 1 (sICAM-1), and soluble VEGF receptor-2 (sVEGFR-2) was evaluated to investigate the role of inflammation in BRVO associated with macular edema. Aqueous flare values and the vitreous levels of VEGF, IL-6, MCP-1, sICAM-1, and sVEGFR-2 were compared between previously untreated patients with BRVO and patients with macular hole (MH).

Methods: Vitreous samples were obtained from 45 patients during vitreoretinal surgery (28 patients with BRVO and 17 with MH), and the levels of VEGF, IL-6, MCP-1, sICAM-1, and sVEGFR-2 were measured by enzyme-linked immunosorbent assay. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion using fluorescein angiography and the Scion Image program. Aqueous flare values were measured with a laser flare meter and macular edema was examined by optical coherence tomography.

Results: The median aqueous flare value was significantly higher in the BRVO group (12.1 photon counts/ms) than in the MH group (4.5 photon counts/ms, P < 0.001). There were significant correlations between the aqueous flare value and the vitreous levels of VEGF, IL-6, MCP-1, and sICAM-1 in the BRVO group (ρ = 0.54, P = 0.005; ρ = 0.56, P = 0.004; ρ = 0.52, P = 0.006; and ρ = 0.47, P = 0.015, respectively). The aqueous flare value was also significantly correlated with the foveal thickness in the BRVO group (ρ = 0.40, P = 0.037).

Conclusions: Inflammation may induce an increase of vascular permeability and disrupt the blood-aqueous barrier via release of inflammatory factors (VEGF, IL-6, MCP-1, and sICAM-1) in BRVO patients with macular edema.

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Figures

Figure 1
Figure 1
Aqueous flare value in the control group (macular hole) and in the patients with branch retinal vein occlusion (BRVO) and macurla edema. The flare value was significantly higher in the BRVO group than in the MH group (*P < 0.001).
Figure 2
Figure 2
Correlation between the aqueous flare value and the nonperfused area of the retina. The aqueous flare value was significantly correlated with the nonperfused area of the retina in BRVO group (ρ = 0.55, P = 0.002).
Figure 3
Figure 3
Correlations between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, soluble intercellular adhesion molecule 1 (sICAM-1), and soluble VEGF receptor-2 (sVEGFR-2). There were significant correlations between the flare value and vitreous levels of VEGF (A), IL-6 (B), MCP-1 (C), sICAM-1 (D), and sVEGFR-2 (E) in the BRVO group (ρ = 0.54, P = 0.005; ρ = 0.56, P = 0.004; ρ = 0.52, P = 0.006; ρ = 0.47, P = 0.015; and ρ = 0.20, P = 0.295, respectively).
Figure 4
Figure 4
Correlation between the aqueous flare value and the foveal thickness. The aqueous flare value was significantly correlated with the foveal thickness in the BRVO group (ρ = 0.40, P = 0.037).
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