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Clinical Trial
. 2014 May 19:15:80.
doi: 10.1186/1471-2369-15-80.

KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods

Kook-Hwan Oh, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae Hyun Yoo, Kyubeck Lee, Yong-Soo Kim, Wookyung Chung, Young-Hwan Hwang, Soo Wan Kim, Yeong Hoon Kim, Sun Woo Kang, Byung-Joo Park, Joongyub Lee, Curie Ahn  1 ; Representing KNOW-CKD Study Group
Collaborators, Affiliations
Clinical Trial

KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods

Kook-Hwan Oh et al. BMC Nephrol. .

Abstract

Background: The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis).

Methods/design: Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50% decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease.

Discussion: As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease.

Trial registration: No. NCT01630486 at http://www.clinicaltrials.gov.

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Figures

Figure 1
Figure 1
Age-adjusted modified Charlson comorbidity index in total and subgroup participants, KNOW-CKD 2011–2013. Abbreviations: GN, glomerulonephritis; DN, diabetic nephropathy; HTN, hypertensive nephropathy; PKD, polycystic kidney disease.
See this image and copyright information in PMC

References

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