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Randomized Controlled Trial
. 2014 May 24:13:96.
doi: 10.1186/1475-2840-13-96.

A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus--a randomized controlled trial START-J study

Toshiyuki Hibuse, Norikazu Maeda  1 , Ken Kishida, Takekazu Kimura, Tomoko Minami, Eriko Takeshita, Ayumu Hirata, Yasuhiko Nakagawa, Susumu Kashine, Akemi Oka, Masumi Hayashi, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura
Affiliations
Randomized Controlled Trial

A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus--a randomized controlled trial START-J study

Toshiyuki Hibuse et al. Cardiovasc Diabetol. .

Abstract

Background: The dipeptidyl-peptidase-IV (DPP-4) inhibitors, including sitagliptin, are used for the treatment of type 2 diabetes mellitus (T2DM). Adiponectin, an adipocyte-derived circulating protein, has anti-atherosclerotic and anti-diabetic properties and is effectively elevated in bloodstream by thiazolidinediones, an insulin sensitizer. However, the effect of sitagliptin treatment on serum adiponectin level in T2DM has not fully elucidated in Japanese T2DM patients. The aim of the present study was to examine the effect of sitagliptin treatment on serum adiponectin levels in T2DM subjects.

Methods: Twenty-six consecutive Japanese T2DM outpatients were recruited between April 2011 and March 2013, and randomized into the control (conventional treatment, n = 10) group and sitagliptin treatment group (n = 16). Serum adiponectin was measured by enzyme-linked immunosorbent assay.

Results: Indices of glycemic control, such as hemoglobin A1c, glycated albumin, and 1.5-anhydro-D-glucitol, were significantly improved after the three-month treatment in both the control and sitagliptin groups. Serum adiponectin level was significantly increased in sitagliptin group from 6.7 ± 0.8 to 7.4 ± 1.0 μg/mL without change of body mass index (p = 0.034), while serum adiponectin level was not altered in the control group (p = 0.601).

Conclusion: In Japanese T2DM patients, serum adiponectin level was elevated by three-month treatment with sitagliptin without change of body weight.

Trial registration: UMIN000004721.

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Figures

Figure 1
Figure 1
Flowchart of START-J study protocol.
Figure 2
Figure 2
Plasma glucose and insulin curves under 75 g-OGTT at baseline and three months. Plasma glucose (A) and serum insulin (B) under 75-gram oral glucose tolerance test (75 g-OGTT) at baseline (A and B, respectively) and 3 months after treatment (C and D, respectively). Data are mean ± SEM of 9 patients of the control group and 12 patients of the sitagliptin group.
Figure 3
Figure 3
Changes in serum TBARS, hsCRP, and adiponectin levels. Serum levels of thiobarbituric acid-reacting substance (TBARS) (A), high-sensitivity C-reactive protein (hsCRP) (B), and adiponectin (C). Data are mean ± SEM of 10 subjects of the control group and 16 subjects of the sitagliptin group. NS; not significant.
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