Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014 May 23:14:34.
doi: 10.1186/1471-2482-14-34.

Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis

Haixing Luan, Feng Ye, Lupeng Wu, Yanming Zhou  1 , Jie Jiang
Affiliations
Meta-Analysis

Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis

Haixing Luan et al. BMC Surg. .

Abstract

Background: It is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the prognosis of patients who underwent lung cancer resection.

Methods: Eligible studies were identified through a computerized literature search. The pooled relative risk ratio (RR) with 95% confidence interval (CI) was calculated using Review Manager 5.1 Software.

Results: Eighteen studies with a total of 5915 participants were included for this meta-analysis. Pooled analysis showed that perioperative blood transfusion was associated with worse overall survival (RR: 1.25, 95% CI: 1.13-1.38; P <0.001) and recurrence-free survival (RR: 1.42, 95% CI: 1.20-1.67; P <0.001) in patients with resected lung cancer.

Conclusions: Perioperative blood transfusion appears be associated with a worse prognosis in patients undergoing lung cancer resection. These data highlight the importance of minimizing blood transfusion during surgery.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Forest plot showing the impact of perioperative blood transfusion on overall survival.
Figure 2
Figure 2
Forest plot showing the impact of perioperative blood transfusion on recurrence-free survival.
Figure 3
Figure 3
Funnel plot analysis of publication bias. The outcome was overall survival.
See this image and copyright information in PMC

References

    1. Gascon P, Zoumbos NC, Young NS. Immunological abnormalities in patients receiving multiple blood transfusions. Ann Intern Med. 1984;100:173–177. doi: 10.7326/0003-4819-100-2-173. - DOI - PubMed
    1. Tartter PI, Burrows L, Kirschner P. Perioperative blood transfusion adversely affects prognosis after resection of stage I (subset NO) non-oat cell lung cancer. J Thorac Cardiovasc Surg. 1984;88:659–662. - PubMed
    1. Hyman NH, Foster RS Jr, DeMeules JE, Costanza MC. Blood transfusions and survival after lung cancer resection. Am J Surg. 1985;149:502–507. doi: 10.1016/S0002-9610(85)80047-7. - DOI - PubMed
    1. Moores DW, Piantadosi S, McKneally MF. Effect of perioperative blood transfusion on outcome in patients with surgically resected lung cancer. Ann Thorac Surg. 1989;47:346–351. doi: 10.1016/0003-4975(89)90371-8. - DOI - PubMed
    1. Little AG, Wu HS, Ferguson MK, Ho CH, Bowers VD, Segalin A, Staszek VM. Perioperative blood transfusion adversely affects prognosis of patients with stage I non-small-cell lung cancer. Am J Surg. 1990;160:630–632. doi: 10.1016/S0002-9610(05)80762-7. - DOI - PubMed