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Review
. 2014 May 11:12:147.
doi: 10.1186/1477-7819-12-147.

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis in the colon: a case report and literature review

Hung-Hsin Lin, Jeng-Kai Jiang, Jen-Kou Lin  1
Affiliations
Review

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis in the colon: a case report and literature review

Hung-Hsin Lin et al. World J Surg Oncol. .

Abstract

This report presents a case of collision tumors of low-grade B-cell lymphoma and adenocarcinoma in the sigmoid colon of an 81-year-old man. All surgically resected regional mesenteric lymph nodes were found to be occupied by low-grade B-cell lymphoma, and one lymph node showed the presence of adenocarcinoma. Low-grade B-cell lymphoma was also observed in the resected spleen. Moreover, concurrent tuberculosis infection in the resected colon was proven by the presence of positive results obtained with polymerase chain reaction analysis of the mycobacterial DNA. Systemic chemotherapy was administered for advanced colon cancer with lung metastasis, and anti-tuberculosis treatment was also prescribed. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectal region is rare. Furthermore, collisions of these different entities are also extremely unusual. The accurate clinical determination of the dominant tumor and a timely follow-up are required for the proper treatment of these cases.

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Figures

Figure 1
Figure 1
Histological appearance of the lung biopsy specimen. Malignant tumor cells were arranged in clusters and an acinar pattern, suggestive of adenocarcinoma. (A) Positive immunohistochemical staining for cytokeratin 20. (B) Positive immunohistochemical staining for caudal-related homeodomain transcription factor 2. (C) Negative immunohistochemical staining for cytokeratin 7. (D) Negative immunohistochemical staining for thyroid transcription factor-1.
Figure 2
Figure 2
Computed tomography (CT) of the abdomen and chest. (A) Abdominal CT revealed wall thickening of the sigmoid colon, which is compatible with colon cancer (arrow). (B) Chest CT revealed a 3.2-cm nodule in the right middle lung field (arrow).
Figure 3
Figure 3
The spleen was infiltrated by low-grade B-cell lymphoma with the proliferation of small-to-medium-sized cells. Hematoxylin and eosin, original magnification, ×100.
See this image and copyright information in PMC

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