Secondary prevention trials in Alzheimer disease: the challenge of identifying a meaningful end point
- PMID: 24886838
- PMCID: PMC4375727
- DOI: 10.1001/jamaneurol.2014.1120
Secondary prevention trials in Alzheimer disease: the challenge of identifying a meaningful end point
Comment on
-
The preclinical Alzheimer cognitive composite: measuring amyloid-related decline.JAMA Neurol. 2014 Aug;71(8):961-70. doi: 10.1001/jamaneurol.2014.803. JAMA Neurol. 2014. PMID: 24886908 Free PMC article.
Similar articles
-
The preclinical Alzheimer cognitive composite: measuring amyloid-related decline.JAMA Neurol. 2014 Aug;71(8):961-70. doi: 10.1001/jamaneurol.2014.803. JAMA Neurol. 2014. PMID: 24886908 Free PMC article.
-
Disease staging and milestones.Can J Neurol Sci. 2007 Mar;34 Suppl 1:S62-6. doi: 10.1017/s031716710000559x. Can J Neurol Sci. 2007. PMID: 17469685 Review.
-
Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease.J Alzheimers Dis. 2005 Jun;7(3):235-9; discussion 255-62. doi: 10.3233/jad-2005-7306. J Alzheimers Dis. 2005. PMID: 16006667 No abstract available.
-
Use of High-Frequency In-Home Monitoring Data May Reduce Sample Sizes Needed in Clinical Trials.PLoS One. 2015 Sep 17;10(9):e0138095. doi: 10.1371/journal.pone.0138095. eCollection 2015. PLoS One. 2015. PMID: 26379170 Free PMC article.
-
Amyloid-dependent and amyloid-independent stages of Alzheimer disease.Arch Neurol. 2011 Aug;68(8):1062-4. doi: 10.1001/archneurol.2011.70. Epub 2011 Apr 11. Arch Neurol. 2011. PMID: 21482918 Review. No abstract available.
Cited by
-
Composite cognitive and functional measures for early stage Alzheimer's disease trials.Alzheimers Dement (Amst). 2020 May 15;12(1):e12017. doi: 10.1002/dad2.12017. eCollection 2020. Alzheimers Dement (Amst). 2020. PMID: 32432155 Free PMC article.
-
Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.Cell Metab. 2015 Nov 3;22(5):761-76. doi: 10.1016/j.cmet.2015.08.016. Epub 2015 Sep 10. Cell Metab. 2015. PMID: 26365177 Free PMC article. Review.
-
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial.PLoS One. 2017 Feb 10;12(2):e0170547. doi: 10.1371/journal.pone.0170547. eCollection 2017. PLoS One. 2017. PMID: 28187125 Free PMC article. Clinical Trial.
-
Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial.PLoS One. 2015 Jul 9;10(7):e0131647. doi: 10.1371/journal.pone.0131647. eCollection 2015. PLoS One. 2015. PMID: 26158265 Free PMC article. Clinical Trial.
-
Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials.J Neurol Neurosurg Psychiatry. 2020 Nov;91(11):1201-1209. doi: 10.1136/jnnp-2019-321913. Epub 2020 Jul 20. J Neurol Neurosurg Psychiatry. 2020. PMID: 32690803 Free PMC article.
References
-
- Pillai JA, Cummings JL. Clinical trials in predementia stages of Alzheimer disease. Med Clin North Am. 2013;97(3):439–457. - PubMed
-
- Kryscio RJ, Mendiondo MS, Schmitt FA, Markesbery WR. Designing a large prevention trial: statistical issues. Stat Med. 2004;23:285–296. - PubMed
-
- Carrillo MC, Brashaer R, Logovinsky V, et al. Can we prevent Alzheimer's disease secondary “prevention” trials in Alzheimer's disease. Alzheimers Dement. 2013;9(2):123–131. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical