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. 2014 May 30;19(6):7138-51.
doi: 10.3390/molecules19067138.

Acute and 4-week repeated-dose oral toxicity studies of Cirsium setidens in rats

Jong Seok Lee  1 , Young-Hyun Kim  2 , Dan-Bi Kim  3 , Woo-Suk Bang  4 , Ok-Hwan Lee  5
Affiliations

Acute and 4-week repeated-dose oral toxicity studies of Cirsium setidens in rats

Jong Seok Lee et al. Molecules. .

Abstract

Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Growth curves for SD rats treated with C. setidens for 4 weeks. (● ○) Group 1 (control); (■ □) Group 2 (1250 mg/kg body weight per day); (▼ ▽) Group 3 (2500 mg/kg body weight per day); (◆ ◇) Group 4 (5000 mg/kg body weight per day).
See this image and copyright information in PMC

References

    1. Shri J. Ginger: It’s role in xenobiotic metabolism. ICMR Bull. 2003;33:57–63.
    1. Tapsell L.C., Hemphill I., Cobiac L., Patch C.S., Sullivan D.R., Fenech M., Roodenrys S., Keogh J.B., Clifton P.M., Williams P.G., et al. Health benefits of herbs and spices: The past, the present, the future. Med. J. Aust. 2006;185:S4–S24. - PubMed
    1. Martinez-Vazquez M., Ramirez Apan T.O., Lastra A.L., Bye R. A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata. Planta Med. 1998;64:134–137. - PubMed
    1. Tundis R., Deguin B., Loizzo M.R., Bonesi M., Statti G.A., Tillequin F., Menichini F. Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Bioorg. Med. Chem. Lett. 2005;15:4757–4760. - PubMed
    1. Liu S., Luo X., Li D., Zhang J., Qiu D., Liu W., She L., Yang Z. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int. Immunopharmacol. 2006;6:1387–1393. - PubMed

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