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. 2014 Dec:99:191-7.
doi: 10.1016/j.fitote.2014.05.019. Epub 2014 Jun 2.

Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis

Ni-Man Bao  1 , Yin Nian  2 , Guo-Lei Zhu  2 , Wei-Hua Wang  2 , Lin Zhou  2 , Ming-Hua Qiu  3
Affiliations

Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis

Ni-Man Bao et al. Fitoterapia. 2014 Dec.

Abstract

Six new 9,19-cycloartane triterpenes (1-6) were isolated from the aerial parts of Cimicifuga yunnanensis. The new chemical structures were determined by extensive analyses of 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first 9,19-cycloartane triterpenes characterized by CH₃-18 shifting from C-13 to C-12 in the Cimicifuga spp. The evaluation of inhibition activity against human HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines indicated that compounds 1-6 showed different levels of cytotoxic activities with IC₅₀ values ranging from 1.2 to 27.8 μm.

Keywords: 18(13→12)Abeo-9,19-cycloartane triterpenes; Cimicifuga yunnanensis; Cytotoxicity.

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