Anti-HIV drug particles may overcome lymphatic drug insufficiency and associated HIV persistence
- PMID: 24889644
- PMCID: PMC4078825
- DOI: 10.1073/pnas.1406554111
Anti-HIV drug particles may overcome lymphatic drug insufficiency and associated HIV persistence
Conflict of interest statement
The authors declare no conflict of interest.
Comment on
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues.Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2307-12. doi: 10.1073/pnas.1318249111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469825 Free PMC article.
References
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- Kinman L, et al. Lipid-drug association enhanced HIV-1 protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: A proof of concept study in HIV-2287–infected macaques. J Acquir Immune Defic Syndr. 2003;34(4):387–397. - PubMed
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- Kinman L, et al. Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques. J Acquir Immune Defic Syndr. 2006;42(2):155–161. - PubMed
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