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. 2014 Aug 11;53(33):8722-6.
doi: 10.1002/anie.201402542. Epub 2014 May 30.

Hydrogenation of esters to alcohols with a well-defined iron complex

Svenja Werkmeister  1 , Kathrin Junge, Bianca Wendt, Elisabetta Alberico, Haijun Jiao, Wolfgang Baumann, Henrik Junge, Fabrice Gallou, Matthias Beller
Affiliations

Hydrogenation of esters to alcohols with a well-defined iron complex

Svenja Werkmeister et al. Angew Chem Int Ed Engl. .

Abstract

We present the first base-free Fe-catalyzed ester reduction applying molecular hydrogen. Without any additives, a variety of carboxylic acid esters and lactones were hydrogenated with high efficiency. Computations reveal an outer-sphere mechanism involving simultaneous hydrogen transfer from the iron center and the ligand. This assumption is supported by NMR experiments.

Keywords: alcohols; esters; homogeneous catalysis; hydrogenation; iron.

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