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Case Reports
. 2014 Jul;91(1):84-5.
doi: 10.4269/ajtmh.14-0058. Epub 2014 Jun 2.

Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome

Kosuke Yasukawa  1 , Shital M Patel  2 , Charlene A Flash  2 , Charles E Stager  2 , Jerry C Goodman  2 , Laila Woc-Colburn  2
Affiliations
Case Reports

Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome

Kosuke Yasukawa et al. Am J Trop Med Hyg. 2014 Jul.

Abstract

As a result of global migration, a significant number of people with Trypanosoma cruzi infection now live in the United States, Canada, many countries in Europe, and other non-endemic countries. Trypanosoma cruzi meningoencephalitis is a rare cause of ring-enhancing lesions in patients with acquired immunodeficiency syndrome (AIDS) that can closely mimic central nervous system (CNS) toxoplasmosis. We report a case of CNS Chagas reactivation in an AIDS patient successfully treated with benznidazole and antiretroviral therapy in the United States.

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Figures

Figure 1.
Figure 1.
Trypanosoma cruzi trypomastigotes in cerebrospinal fluid (CSF) (Giemsa stain, ×1,000).
Figure 2.
Figure 2.
Trypanosoma cruzi amastigotes with rod-shaped kinetoplasts in glial cells (Giemsa stain, ×1,000).
See this image and copyright information in PMC

References

    1. Silva N, O'Bryan L, Medeiros E, Holand H, Suleiman J, de Mendonca JS, Patronas N, Reed SG, Klein HG, Masur H, Badaro R. Trypanosoma cruzi meningoencephalitis in HIV-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20:342–349. - PubMed
    1. Cordova E, Boschi A, Ambrosioni J, Cudos C, Corti M. Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007. Int J Infect Dis. 2008;12:587–592. - PubMed
    1. Gluckstein D, Ciferri F, Ruskin J. Chagas' disease: another cause of cerebral mass in the acquired immunodeficiency syndrome. Am J Med. 1992;92:429–432. - PubMed
    1. Yoo TW, Mlikotic A, Cornford ME, Beck CK. Concurrent cerebral American trypanosomiasis and toxoplasmosis in a patient with AIDS. Clin Infect Dis. 2004;39:e30–e34. - PubMed
    1. Lambert N, Mehta B, Walters R, Eron JJ. Chagasic encephalitis as the initial manifestation of AIDS. Ann Intern Med. 2006;144:941–943. - PubMed

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