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Review
. 2014 Aug;19(8):1217-21.
doi: 10.1016/j.drudis.2014.05.008. Epub 2014 Jun 2.

Protein kinase C inhibitors for immune disorders

Amnon Altman  1 , Kok-Fai Kong  2
Affiliations
Review

Protein kinase C inhibitors for immune disorders

Amnon Altman et al. Drug Discov Today. 2014 Aug.

Abstract

Protein kinase C (PKC) proteins are a group of well-conserved, intracellular signaling enzymes expressed in all cells and tissues, including immune cells. Much of the molecular insight into PKC immunobiology has been gleaned from studies using PKC gene (Prkc) knockout mice and the analysis of different disease models in these animals. More-recent studies have revealed that PKCs also have crucial roles in the pathogenesis of human immune disorders. Therefore, strategies to modulate the functions of PKC enzymes could have a major impact on the treatment and therapies of autoimmune diseases and other immune disorders.

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Conflict of interest statement

Conflicts of interest

The authors have no conflicts of interest to declare.

References

    1. Steinberg SF. Structural basis of protein kinase C isoform function. Physiol. Rev. 2008;88:1341–1378. - PMC - PubMed
    1. Soloff RS, et al. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J. Immunol. 2004;173:3250–3260. - PubMed
    1. Pfeifhofer C, et al. Defective IgG2a/2b class switching in PKC alpha−/− mice. J. Immunol. 2006;176:6004–6011. - PubMed
    1. Su TT, et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 2002;3:780–786. - PubMed
    1. Miyamoto A, et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002;416:865–869. - PubMed

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