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. 2014 Jun 20;16(12):3372-5.
doi: 10.1021/ol501400u. Epub 2014 Jun 3.

Copper-catalyzed direct trifluoromethylthiolation of benzylic C-H bonds via nondirected oxidative C(sp3)-H activation

Chao Chen  1 , Xiu-Hua Xu, Bin Yang, Feng-Ling Qing
Affiliations

Copper-catalyzed direct trifluoromethylthiolation of benzylic C-H bonds via nondirected oxidative C(sp3)-H activation

Chao Chen et al. Org Lett. .

Abstract

A copper-catalyzed trifluoromethylthiolation of benzylic sp(3) C-H bonds was developed via nondirected oxidative C-H activation using readily prepared and stable AgSCF3. This reaction provides a novel and straightforward method for the preparation of various benzyl trifluoromethyl sulfides.

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