Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jun 4;311(21):2225-6.
doi: 10.1001/jama.2014.4929.

Prophylactic antibiotic therapy in chronic obstructive pulmonary disease

Samantha C Herath  1 , Phillippa Poole  2
Affiliations
Comment

Prophylactic antibiotic therapy in chronic obstructive pulmonary disease

Samantha C Herath et al. JAMA. .

Abstract

CLINICAL QUESTION Is prophylactic antibiotic treatment associated with fewer exacerbations or improved health-related quality of life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD)? BOTTOM LINE Continuous macrolide antibiotic use for prophylaxis was associated with a clinically significant reduction in COPD exacerbations. Pulsed antibiotic use was not associated with benefit. Continuous and pulsed antibiotics were associated with improved HRQOL, but this was not clinically significant.

PubMed Disclaimer

Comment on

MeSH terms

Substances