Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jul 21;50(57):7632-5.
doi: 10.1039/c4cc02595d.

A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis

Jung Min Shin  1 , Seol-Hee Kim, Thavasyappan Thambi, Dong Gil You, Jueun Jeon, Jong Oh Lee, Bong Youl Chung, Dong-Gyu Jo, Jae Hyung Park
Affiliations

A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis

Jung Min Shin et al. Chem Commun (Camb). .

Abstract

In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.

PubMed Disclaimer

Publication types

MeSH terms