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. 2014 Mar-Apr;34(2):122-7.
doi: 10.5144/0256-4947.2014.122.

Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients

Hamid Najmaddini, Gholamhossein Hassanshahi, Hamid Ostadebrahimi, Hoda Barkhordari, Habibeh Mashayekhi, Mina Nazari, Mozhgan Moogooei, Yassin Safari Arababadi, Fatemeh Peighambari, Mojgan Noroozi Karimabad  1
Affiliations

Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients

Hamid Najmaddini et al. Ann Saudi Med. 2014 Mar-Apr.

Abstract

Backgrounds and objectives: B-thalassemia major is one of the most frequent hematological genetic disorders, worldwide. Chemokines are the main components of the immune system and play fundamental roles in pathogenesis of inflammatory disorders. Therefore, the present study aimed to examine whether serum CXC chemokines are altered in b-thalassemia major patients.

Design and settings: We enrolled 63 b-thalassemia patients and 80 controls in this cross-sectional study, which was performed during 2012-2013 in Kerman, Iran.

Methods: We enrolled 63 b-thalassemia patients and 80 controls in the present study. Patients were selected from referrals to Samenolhojaj clinic for thalassemia, Kerman, Iran. The circulating levels of CXCL1, CXCL9, CXCL10, and CXCL12 were detected by enzyme-linked immunosorbent assay in thalassemia patients and healthy controls immediately after blood collection. Data were analyzed by c2, t-test, and analysis of variance statistical methods and using SPSS, version 13 (SPSS Inc., Chicago, IL).

Results: The results of the study demonstrated a significant elevation of CXCL1, CXCL9, CXCL10, and CXCL12 in thalassemia patients than in control. These results also demonstrated that serum chemokine levels are related to transfusion duration and post-transfusion viral infections.

Conclusion: According to the results obtained, it can probably be concluded that chemokines are also involved in the pathogenesis of b-thalassemia major and its clinical complications in addition to several other parameters.

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Conflict of interest statement

Conflict of interest

None of authors of this study claimed conflict of interest.

Figures

Figure 1
Figure 1
Circulating levels of CXCL10 in β-thalassemia major patients and controls. Significant difference with control (P<.05).
Figure 2
Figure 2
Circulating levels of CXCL1 β-thalassemia major patients and control. Significant difference with control (P<.03).
Figure 3
Figure 3
Circulating levels of CXCL9 in β-thalassemia major patients and control. Significant difference with (P<.05).
Figure 4
Figure 4
Circulating levels of CXCL12 in β-thalassemia major patients and control. Significant difference with control (P=.05).
See this image and copyright information in PMC

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