Is there a need to add another dimension (time) to the evaluation of the arrhythmogenic potential of new drug candidates in vitro?
- PMID: 24895458
- DOI: 10.1161/CIRCULATIONAHA.114.010819
Is there a need to add another dimension (time) to the evaluation of the arrhythmogenic potential of new drug candidates in vitro?
Keywords: Editorials; arrhythmias, cardiac; phosphatidylinositol 3-kinase; safety; sodium channels.
Comment on
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Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.Circulation. 2014 Jul 15;130(3):224-34. doi: 10.1161/CIRCULATIONAHA.113.007765. Epub 2014 Jun 3. Circulation. 2014. PMID: 24895457 Free PMC article.
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