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Case Reports
. 2013 Mar;47(1):55-60.
doi: 10.1007/s13139-012-0180-6. Epub 2012 Oct 15.

Paraneoplastic Cerebellar Degeneration as Initial Presentation of Papillary Carcinoma of the Fallopian Tube: Evaluation and Usefulness of (18)F-FDG PET-CT. Case Report and Literature Review

Nayelli Ortega López  1 , Digna Pachuca González  1 , José Alfonso Rumoroso García  1 , Juan Carlos García Reyna  1 , Luis Felipe Alva López  1
Affiliations
Case Reports

Paraneoplastic Cerebellar Degeneration as Initial Presentation of Papillary Carcinoma of the Fallopian Tube: Evaluation and Usefulness of (18)F-FDG PET-CT. Case Report and Literature Review

Nayelli Ortega López et al. Nucl Med Mol Imaging. 2013 Mar.

Abstract

The acquisition of an (18)F-FDG PET-CT scan in patients with suspected paraneoplastic cerebellar syndrome can be helpful in determining the origin of a neoplasm because of its high sensitivity and also helps guide the neurological development course depending on the degree of incorporation of (18)F-FDG to the cerebellar parenchyma when compared with the rest of the brain.

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Figures

Fig. 1
Fig. 1
Initial MRI findings were normal. a Non-contrast-enhanced sagittal-slice T1-weighted image. b, c, and d Sagittal, coronal, and trans-axial T2-weighted image, respectively
Fig. 2
Fig. 2
18F-FDG PET-CT brain scan. a 3D fused PET-CT sagittal slice and MIP reconstruction show increased metabolism in both cerebellar hemispheres. b 3D fused PET-CT axial slices. c Whole-brain axial slices
Fig. 3
Fig. 3
18F-FDG whole body PET-CT. a and b MIP coronal reconstruction showing a focal hypermetabolism in the left pelvis, corresponding to the site of the primary tumor (Fallopian tube topography) (arrowhead). c Right inguinal lymphadenopathy and a spleen focal lesion corresponding to metastatic disease (thick arrow)
Fig. 4
Fig. 4
Hematoxylin-eosin staining shows edema in the villi of the Fallopian tubes, semi-solid and papillary formation of neoplastic cells. a Normal tissue); b neoplastic tissue
Fig. 5
Fig. 5
18F-FDG PET-CT brain scan after immunoglobulin and oncological therapy. a 3D fused PET-CT sagittal slice and b MIP reconstruction show decreased metabolism in both cerebellar hemispheres. c 3D fused PET-CT axial slices. d Whole brain axial slices
See this image and copyright information in PMC

References

    1. Castelnovo G, et al. FDG-PET hypermetabolism in paraneoplastic cerebellar degeneration. Acta Neurolg Belg. 2011;111(2):165. - PubMed
    1. Choi KD, et al. Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration. J Neurol Neurosurg Psychiatry. 2006;77(4):525–528. doi: 10.1136/jnnp.2005.075325. - DOI - PMC - PubMed
    1. Dalmau J, Rasenfeld MR. Paraneoplastic syndromes of the CSN. Lancet Neurol. 2008;7(4):327–340. doi: 10.1016/S1474-4422(08)70060-7. - DOI - PMC - PubMed
    1. Marchand V, et al. A rare gynecological case of paraneoplastic cerebellar degeneration discovered by FDG-PET. Gynecol Oncol. 2007;105(2):545–547. doi: 10.1016/j.ygyno.2007.01.047. - DOI - PubMed
    1. Shinohara Y, et al. Detection of primary tumor in paraneoplastic cerebellar degeneration by FDG-PET. Ann Neurol. 1998;43(5):684. doi: 10.1002/ana.410430522. - DOI - PubMed

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