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Review
. 2014 Jan-Mar;29(1):93-102.
doi: 10.5935/1678-9741.20140017.

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

[Article in English, Portuguese]
Gabriel Romero Liguori, Alexandre Fligelman Kanas, Luiz Felipe Pinho Moreira
Review

Managing the inflammatory response after cardiopulmonary bypass: review of the studies in animal models

[Article in English, Portuguese]
Gabriel Romero Liguori et al. Rev Bras Cir Cardiovasc. 2014 Jan-Mar.

Abstract
in English, Portuguese

Objective: To review studies performed in animal models that evaluated therapeutic interventions to inflammatory response and microcirculatory changes after cardiopulmonary bypass.

Methods: It was used the search strategy ("Cardiopulmonary Bypass" (MeSH)) and ("Microcirculation" (MeSH) or "Inflammation" (MeSH) or "Inflammation Mediators" (MeSH)). Repeated results, human studies, non-English language articles, reviews and studies without control were excluded.

Results: Blood filters, system miniaturization, specific primers regional perfusion, adequate flow and temperature and pharmacological therapies with anticoagulants, vasoactive drugs and anti-inflammatories reduced changes in microcirculation and inflammatory response.

Conclusion: Demonstrated efficacy in animal models establishes a perspective for evaluating these interventions in clinical practice.

Objetivo: Revisar estudos realizados em modelos animais avaliando intervenções terapêuticas e resposta inflamatória e alterações da microcirculação após instalação de circulação extracorpórea.

Métodos: Utilizada a estratégia de busca ("Cardiopulmonary Bypass"(MeSH)) AND ("Microcirculation"(MeSH) OR "Inflammation"(MeSH) OR "Inflammation Mediators"(MeSH)). Resultados repetidos, estudos humanos, artigos em língua não inglesa, revisões e estudos sem controle foram excluídos.

Resultados: Filtros sanguíneos, miniaturização do sistema, perfusatos específicos, perfusão regional, fluxo e temperatura adequados e terapias farmacológicas com fármacos anticoagulantes, vasoativos e anti-inflamatórios reduziram alterações em microcirculação e resposta inflamatória.

Conclusão: A eficácia demonstrada em modelos animais estabelece uma perspectiva para avaliação dessas intervenções na prática clínica.

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Figures

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Fig. 1
Chart showing the search strategy of the articles until reaching the final number
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