Father-son chats: inheriting stress through sperm RNA
- PMID: 24896534
- PMCID: PMC4131544
- DOI: 10.1016/j.cmet.2014.05.015
Father-son chats: inheriting stress through sperm RNA
Abstract
Although mounting evidence in mammals suggests that certain ancestral environmental exposures can influence the phenotype in future generations, mechanisms underlying such intergenerational information transfer remain unclear. A recent report suggests that RNA isolated from sperm can inform offspring of a father's history of early life trauma (Gapp et al., 2014).
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.Nat Neurosci. 2014 May;17(5):667-9. doi: 10.1038/nn.3695. Epub 2014 Apr 13. Nat Neurosci. 2014. PMID: 24728267 Free PMC article.
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- Garcia-Lopez J, de Dios Hourcade J, Alonso L, Cardenas DB, Del Mazo J. Global characterization and target identification of piRNAs and endo-siRNAs in mouse gametes and zygotes. Biochimica et biophysica acta 2014 - PubMed
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