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Comment
. 2014 Jun 3;19(6):900-1.
doi: 10.1016/j.cmet.2014.05.007.

Fat or fiction: origins matter

Derrick C Wan  1 , Michael T Longaker  2
Affiliations
Free article
Comment

Fat or fiction: origins matter

Derrick C Wan et al. Cell Metab. .
Free article

Abstract

Cell-lineage tracing has revealed a complex heterogeneity present in postnatal tissue and adult progenitors. Chau et al. (2014) and Long et al. (2014) provide further evidence for this among adipocytes, and their findings underscore the importance of cellular ontogeny not just for development but also for potential treatment of disease.

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  • Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.
    Chau YY, Bandiera R, Serrels A, Martínez-Estrada OM, Qing W, Lee M, Slight J, Thornburn A, Berry R, McHaffie S, Stimson RH, Walker BR, Chapuli RM, Schedl A, Hastie N. Chau YY, et al. Nat Cell Biol. 2014 Apr;16(4):367-75. doi: 10.1038/ncb2922. Epub 2014 Mar 9. Nat Cell Biol. 2014. PMID: 24609269 Free PMC article.
  • A smooth muscle-like origin for beige adipocytes.
    Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ Jr, Rosen ED, Spiegelman BM. Long JZ, et al. Cell Metab. 2014 May 6;19(5):810-20. doi: 10.1016/j.cmet.2014.03.025. Epub 2014 Apr 4. Cell Metab. 2014. PMID: 24709624 Free PMC article.

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