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Comment
. 2014 Aug;34(8):1257.
doi: 10.1038/jcbfm.2014.98. Epub 2014 Jun 4.

Frizzled fissure to improve central nervous system drug delivery?

Lester R Drewes  1
Affiliations
Comment

Frizzled fissure to improve central nervous system drug delivery?

Lester R Drewes. J Cereb Blood Flow Metab. 2014 Aug.

Abstract

Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.

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References

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