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. 2014 Nov;63(11):3938-45.
doi: 10.2337/db13-1891. Epub 2014 Jun 4.

Trends in incidence of type 1 diabetes among non-Hispanic white youth in the U.S., 2002-2009

Jean M Lawrence  1 , Giuseppina Imperatore  2 , Dana Dabelea  3 , Elizabeth J Mayer-Davis  4 , Barbara Linder  5 , Sharon Saydah  6 , Georgeanna J Klingensmith  7 , Lawrence Dolan  8 , Debra A Standiford  9 , Catherine Pihoker  10 , David J Pettitt  11 , Jennifer W Talton  12 , Joan Thomas  13 , Ronny A Bell  14 , Ralph B D'Agostino Jr  12 ; SEARCH for Diabetes in Youth Study Group
Collaborators, Affiliations

Trends in incidence of type 1 diabetes among non-Hispanic white youth in the U.S., 2002-2009

Jean M Lawrence et al. Diabetes. 2014 Nov.

Abstract

The SEARCH for Diabetes in Youth Study prospectively identified youth aged <20 years with physician-diagnosed diabetes. Annual type 1 diabetes (T1D) incidence per 100,000 person-years (95% CI) overall, by age-group, and by sex were calculated for at-risk non-Hispanic white (NHW) youth from 2002 through 2009. Joinpoint and Poisson regression models were used to test for temporal trends. The age- and sex-adjusted incidence of T1D increased from 24.4/100,000 (95% CI 23.9-24.8) in 2002 to 27.4/100,000 (26.9-27.9) in 2009 (P for trend = 0.0008). The relative annual increase in T1D incidence was 2.72% (1.18-4.28) per year; 2.84% (1.12-4.58) per year for males and 2.57% (0.68-4.51) per year for females. After adjustment for sex, significant increases were found for youth aged 5-9 years (P = 0.0023), 10-14 years (P = 0.0008), and 15-19 years (P = 0.004) but not among 0-4-year-olds (P = 0.1862). Mean age at diagnosis did not change. The SEARCH study demonstrated a significant increase in the incidence of T1D among NHW youth from 2002 through 2009 overall and in all but the youngest age-group. Continued surveillance of T1D in U.S. youth to identify future trends in T1D incidence and to plan for health care delivery is warranted.

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Figures

Figure 1
Figure 1
Incidence of T1D among NHW youth aged <20 years at diagnosis overall and by sex and age category: the SEARCH for Diabetes in Youth Study, 2002–2009. A: Total sample. B: Males. C: Females. ■, all youth; ○, 0–4-year-olds; □, 5–9-year-olds; ▲, 10–14-year-olds; ●, 15–19-year-olds.
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