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. 2014 Jun 5:13:218.
doi: 10.1186/1475-2875-13-218.

Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border

Manas Kotepui  1 , Bhukdee Phunphuech, Nuoil Phiwklam, Chaowanee Chupeerach, Suwit Duangmano
Affiliations

Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border

Manas Kotepui et al. Malar J. .

Abstract

Background: Malaria is a major mosquito-borne public health problem in Thailand with varied haematological consequences. The study sought to elucidate the haematological changes in people who suspected malaria infection and their possible predictive values of malaria infection.

Methods: Haematological parameters of 4,985 patients, including 703 malaria-infected and 4,282 non-malaria infected, who admitted at Phop Phra Hospital, Tak Province, an area of malaria endemic transmission in Thailand during 2009 were evaluated.

Results: The following parameters were significantly lower in malaria-infected patients; red blood cells (RBCs) count, haemoglobin (Hb), platelets count, white blood cells (WBCs) count, neutrophil, monocyte, lymphocyte and eosinophil counts, while mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), Mean corpuscular haemoglobin concentration (MCHC), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were higher in comparison to non-malaria infected patients. Patients with platelet counts < 150,000/uL were 31.8 times (odds ratio) more likely to have a malaria infection. Thrombocytopenia was present in 84.9% of malaria-infected patients and was independent of age, gender and nationality (P value < 0.0001).

Conclusion: Patients infected with malaria exhibited important changes in most of haematological parameters with low platelet, WBCs, and lymphocyte counts being the most important predictors of malaria infection. When used in combination with other clinical and microscopy methods, these parameters could improve malaria diagnosis and treatment.

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References

    1. WHO. World malaria report 2012. Geneva: World Health Organization; 2012.
    1. Bakhubaira S. Hematological parameters in severe complicated Plasmodium falciparum malaria among adults in Aden. Turk J Haematol. 2013;30:394–399. doi: 10.4274/Tjh.2012.0086. - DOI - PMC - PubMed
    1. Maina RN, Walsh D, Gaddy C, Hongo G, Waitumbi J, Otieno L, Jones D, Ogutu BR. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malar J. 2010;9(Suppl 3):S4. doi: 10.1186/1475-2875-9-S3-S4. - DOI - PMC - PubMed
    1. van Wolfswinkel ME, Vliegenthart-Jongbloed K, De Mendonca Melo M, Wever PC, McCall MB, Koelewijn R, Van Hellemond JJ, Van Genderen PJ. Predictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria. Malar J. 2013;12:101. doi: 10.1186/1475-2875-12-101. - DOI - PMC - PubMed
    1. Warimwe GM, Murungi LM, Kamuyu G, Nyangweso GM, Wambua J, Naranbhai V, Fletcher HA, Hill AV, Bejon P, Osier FH, Marsh K. The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children. PLoS One. 2013;8:e57320. doi: 10.1371/journal.pone.0057320. - DOI - PMC - PubMed