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. 2011 Sep;45(3):217-9.
doi: 10.1007/s13139-011-0084-x. Epub 2011 May 20.

Assessment of Therapeutic Effect of Sunitinib by (11)C-Acetate PET Compared with FDG PET Imaging in a Patient with Metastatic Renal Cell Carcinoma

Nobuyuki Oyama  1 , Noriko Takahara  1 , Yoko Hasegawa  1 , Kazuya Tanase  1 , Yoshiji Miwa  1 , Hironobu Akino  1 , Hidehiko Okazawa  2 , Takashi Kudo  2 , Yasuhisa Fujibayashi  2 , Osamu Yokoyama  1
Affiliations

Assessment of Therapeutic Effect of Sunitinib by (11)C-Acetate PET Compared with FDG PET Imaging in a Patient with Metastatic Renal Cell Carcinoma

Nobuyuki Oyama et al. Nucl Med Mol Imaging. 2011 Sep.

Abstract

Although sunitinib shows a high response rate in patients with untreated metastatic renal cell carcinoma (mRCC), quite a few patients show no therapeutic effect. Therefore, it is crucial to distinguish the patients who respond to sunitinib from those who do not as early as possible after the administration of the therapy. We herein report a case of mRCC in which (11)C-acetate (AC) positron emission tomography (PET) showed an early therapeutic effect of sunitinib treatment 4 weeks after its administration.

Keywords: 11C-acetate; Positron emission tomography; Renal cell carcinoma; Sunitinib; Therapeutic effect.

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Figures

Fig. 1
Fig. 1
a CT showed a mediastinal lymph node mass. b All lesions stayed the same size after the first cycle of sunitinib
Fig. 2
Fig. 2
a AC PET delineated an osseous lesion at the left temporal bone as well as the lung and lymph nodes. b AC PET showed the disappearance of tracer uptake for the left temporal bone and decreased tracer uptake for the mediastinal lymph nodes after the first cycle of sunitinib. c This osseous lesion was not recognized by FDG PET. d FDG PET demonstrated almost equal tracer uptake for the mediastinal lymph nodes by visual inspection
See this image and copyright information in PMC

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