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. 2011 Dec;45(4):319-23.
doi: 10.1007/s13139-011-0101-0. Epub 2011 Sep 3.

A Case of Urethral Metastasis from Sigmoid Colon Cancer Diagnostically and Prognostically Indicated by F-18 FDG PET/CT

Han Seok Seo  1 , Eun Sil Kim  2 , Soyon Kim  1 , Su Jin Im  1 , Yong Hyun Park  1 , Ju Hyoung Lee  1 , So Chong Hur  1
Affiliations

A Case of Urethral Metastasis from Sigmoid Colon Cancer Diagnostically and Prognostically Indicated by F-18 FDG PET/CT

Han Seok Seo et al. Nucl Med Mol Imaging. 2011 Dec.

Abstract

Urethral metastasis from colorectal cancer is rare and is known to have a poor prognosis. A 72-year-old man with a history of colectomy and colostomy due to sigmoid colon cancer was admitted to the emergency room with bowel distension, rectal bleeding and urinary symptoms. Computed tomography of the abdominopelvis showed sigmoid colon cancer with multiple metastases involving the liver. Positron emission tomography with F-18 fluorodeoxyglucose (FDG) showed multiple hypermetabolic foci in the liver, penis and pubic bone, which otherwise could not be diagnosed. The lesions revealed no improvement with chemotherapy and urological surgery on follow-up F-18 FDG PET/CT. We present a case of urethral metastasis of sigmoid colon cancer diagnostically and prognostically indicated by F-18 FDG PET/CT.

Keywords: F-18 FDG PET/CT; Sigmoid colon cancer; Urethral metastasis.

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Figures

Fig. 1
Fig. 1
Prechemotherapy F-18 FDG PET/CT shows multiple hypermetabolic foci at the liver (arrowheads, large; SUVmax = 9.0, small SUVmax = 6.8), right pubic ramus (curved arrow, SUVmax = 4.9) and penis (arrow, SUVmax = 9.0). Reactive FDG uptakes are noted in the left neck, both hilar and mediastinal lymph nodes, right upper lung and lateral aspect of the right proximal femur. The maximum intensity projection images of PET (A) and fused PET/CT (a–d) are demonstrated
Fig. 2
Fig. 2
Immunohistochemical staining of resected urethral specimen showed tumor cells strongly positive for CK-20 (A, arrow) and scattered pattern for CK-7 (B, arrow)
Fig. 3
Fig. 3
Postchemotherapy F-18 FDG PET/CT shows multiple hypermetabolic foci at the liver (arrowheads, large; SUVmax = 9.9, small SUVmax = 8.3), right obturator muscle including the adjacent pubic ramus (curved arrow, SUVmax = 12.7) and penis (arrow, SUVmax = 11.3). Maximum intensity projection images of PET (A) and fused PET/CT (a-d) are demonstrated
Fig. 4
Fig. 4
Postchemotherapy F-18 FDG PET/CT (B) shows aggravated regional FDG uptakes compared with prechemotherapy F-18 FDG PET/CT (A)
See this image and copyright information in PMC

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