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. 2012 May 24;3(6):442-4.
doi: 10.1021/ml300114c. eCollection 2012 Jun 14.

Drug repurposing and the medicinal chemist

Affiliations

Drug repurposing and the medicinal chemist

Jeffrey Aubé. ACS Med Chem Lett. .

Abstract

Drug repurposing is an approach to finding new uses for older drugs and has been gaining popularity in recent years. The role of traditional medicinal chemistry in the context of these efforts is considered.

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References

    1. For an appraisal of the combinatorial chemistry controversy from a contemporary perspective, see:Kennedy J. P.; Williams L.; Bridges T. M.; Daniels R. N.; Weaver D.; Lindsley C. W. Application of Combinatorial Chemistry Science on Modern Drug Discovery. J. Comb. Chem. 2008, 10, 345–354. - PubMed
    1. Ashburn T. T.; Thor K. B. Drug Repositioning: Identifying and Developing New Uses for Existing Drugs. Nat. Rev. Drug Discov. 2004, 3, 673–683. - PubMed
    1. O’Connor K. A.; Roth B. L. Finding New Tricks for Old Drugs: An Efficient Route for Public-Sector Drug Discovery. Nat. Rev. Drug Discov. 2005, 4, 1005–1014. - PubMed
    1. Oprea T. I.; Bauman J. E.; Bologa C. G.; Buranda T.; Chigaev A.; Edwards B. S.; Jarvik J. W.; Gresham H. D.; Haynes M. K.; Hjelle B.; Hromas R.; Hudson L.; Mackenzie D. A.; Muller C. Y.; Reed J. C.; Simons P. C.; Smagley Y.; Strouse J.; Surviladze Z.; Thompson T.; Ursu O.; Waller A.; Wandinger-Ness A.; Winter S. S.; Wu Y.; Young S. M.; Larson R. S.; Willman C.; Sklar L. A. Drug Repurposing From an Academic Perspective. Drug Discov. Today: Ther. Strategies 2011, 8, 61–69. - PMC - PubMed
    1. Doan T. L.; Pollastri M.; Walters M. A.; Georg G. I.; Macor J., E. . The Future of Drug Repositioning: Old Drugs, New Opportunities. In Annu. Rep. Med. Chem.., Macor J. E., Ed. Academic Press: Oxford, 2011; Vol. 46, pp 385–401.