Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug 2;3(9):688-90.
doi: 10.1021/ml3002105. eCollection 2012 Sep 13.

Four lessons from global health drug discovery: medicine for an ailing industry?

Affiliations

Four lessons from global health drug discovery: medicine for an ailing industry?

Richard L Elliott. ACS Med Chem Lett. .

Abstract

In recent years, the pharmaceutical industry has faced many challenges to its business model, undergoing tremendous change and turmoil to survive. Are there any lessons to be drawn from drug discovery focused on Global Health, where there is little market incentive?

PubMed Disclaimer

Figures

Figure 1
Figure 1
The number of drugs per billion U.S.$ R&D spending over time.
Figure 2
Figure 2
Structures of select Global Health drugs.

References

    1. Reproduced with permission from:Scannell J. W.; Blanckley A.; Boldon H.; Warrington B. Diagnosing the decline in pharmaceutical R&D efficiency. Nature Rev. Drug Discovery 2012, 11, 191–200. - PubMed
    1. Payne D. J.; Gwynn M. N.; Holmes D. J.; Pompliano D. L. Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nature Rev. Drug Discovery 2007, 6, 29–40. - PubMed
    1. Yao F.; MacKenzie R. G. Obesity Drug Update: The Lost Decade?. Pharmaceuticals 2010, 3, 3494–3521.
    1. For more information, go to www.grandchallenges.org/explorations/Pages/introduction.aspx.