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. 2013 Dec 18;5(2):99-101.
doi: 10.1021/ml400472e. eCollection 2014 Feb 13.

Spotlight on fluorescent biosensors-tools for diagnostics and drug discovery

May C Morris  1
Affiliations

Spotlight on fluorescent biosensors-tools for diagnostics and drug discovery

May C Morris. ACS Med Chem Lett. .

Abstract

Fluorescent biosensors constitute potent tools for probing biomolecules in their natural environment and for visualizing dynamic processes in complex biological samples, living cells, and organisms. They are well suited for highlighting molecular alterations associated with pathological disorders, thereby offering means of implementing sensitive and alternative technologies for diagnostic purposes. They constitute attractive tools for drug discovery programs, from high throughput screening assays to preclinical studies.

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Figures

Figure 1
Figure 1
Fluorescent Biosensors—detecting biomolecules in their native environment and monitoring dynamic processes in complex biological samples. Fluorescent biosensors respond to the presence, activity, or conformation of a soluble or secreted target or biomarker, a cell surface antigen, or an intracellular biomolecule, through sensitive, dynamic, and reversible changes in fluorescence of a (or several) fluorescent probe.
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