Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:952624.
doi: 10.1155/2014/952624. Epub 2014 May 13.

Reversible posterior encephalopathy syndrome secondary to sunitinib

Ricardo Costa  1 , Rubens Costa  2 , Renata Costa  3 , Gilberto Moura de Brito Junior  4 , Henrique Queiroz Cartaxo  4 , Alex Caetano de Barros  5
Affiliations

Reversible posterior encephalopathy syndrome secondary to sunitinib

Ricardo Costa et al. Case Rep Oncol Med. 2014.

Abstract

Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Increased T2 uptake sequence on cerebral occipital parietal regions.
Figure 2
Figure 2
Increased fluid-attenuated inversion recovery (FLAIR) uptake sequence on cerebral occipital parietal regions.
See this image and copyright information in PMC

References

    1. Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. The New England Journal of Medicine. 1996;334(8):494–500. - PubMed
    1. Kou R, Greif D, Michel T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. Journal of Biological Chemistry. 2002;277(33):29669–29673. - PubMed
    1. Raps EC, Galetta SL, Broderick M, Atlas SW. Delayed peripartum vasculopathy: cerebral eclampsia revisited. Annals of Neurology. 1993;33(2):222–225. - PubMed
    1. Schwartz RB, Jones KM, Kalina P, et al. Hypertensive encephalopathy: findings on CT, MR imaging, and SPECT imaging in 14 cases. American Journal of Roentgenology. 1992;159(2):379–383. - PubMed
    1. Lazarus M, Amundson S, Belani R. An association between bevacizumab and recurrent posterior reversible encephalopathy syndrome in a patient presenting with deep vein thrombosis: a case report and review of the literature. Case Reports in Oncological Medicine. 2012;2012:4 pages.819546 - PMC - PubMed

LinkOut - more resources