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Review
. 2014 Jun 1;5(3):212-7.
doi: 10.14336/AD.2014.0500212. eCollection 2014 Jun.

Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging

Chandan Prasad  1 , Victorine Imrhan  1 , Francesco Marotta  2 , Shanil Juma  1 , Parakat Vijayagopal  1
Affiliations
Review

Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging

Chandan Prasad et al. Aging Dis. .

Abstract

Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.

Keywords: Aging; glycation; oxidative stress; reactive nitrogen species; reactive oxygen species.

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Figures

Figure 1.
Figure 1.
Relationship between oxidation, modification of essential macromolecules and age-related diseases.
See this image and copyright information in PMC

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