Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014:2014:565320.
doi: 10.1155/2014/565320. Epub 2014 May 8.

HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review

Chi-Yuan Cheng  1 , Shih-Chi Su  2 , Chi-Hua Chen  1 , Wei-Li Chen  1 , Shin-Tarng Deng  1 , Wen-Hung Chung  3
Affiliations
Review

HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review

Chi-Yuan Cheng et al. J Immunol Res. 2014.

Abstract

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.

PubMed Disclaimer

References

    1. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. The New England Journal of Medicine. 1994;331(19):1272–1285. - PubMed
    1. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau J-C. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Archives of Dermatology. 1993;129(1):92–96. - PubMed
    1. Chan HL, Stern RS, Arndt KA, et al. The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: a population-based study with particular reference to reactions caused by drugs among outpatients. Archives of Dermatology. 1990;126(1):43–47. - PubMed
    1. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome(DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergology International. 2006;55(1):1–8. - PubMed
    1. Kano Y, Hiraharas K, Sakuma K, Shiohara T. Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease. British Journal of Dermatology. 2006;155(2):301–306. - PubMed

MeSH terms