Review
doi: 10.1016/0731-7085(89)80042-1.
The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis
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- PMID: 2490111
- DOI: 10.1016/0731-7085(89)80042-1
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Review
The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis
J Pharm Biomed Anal.
1989.
Abstract
The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.
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