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Review
. 1989;7(9):1033-8.
doi: 10.1016/0731-7085(89)80042-1.

The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis

I W Wainer  1
Affiliations
Review

The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis

I W Wainer. J Pharm Biomed Anal. 1989.

Abstract

The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.

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