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Review
. 2014 Jul;124(1):120-133.
doi: 10.1097/AOG.0000000000000346.

Intrahepatic cholestasis of pregnancy

Catherine Williamson  1 , Victoria Geenes
Affiliations
Review

Intrahepatic cholestasis of pregnancy

Catherine Williamson et al. Obstet Gynecol. 2014 Jul.

Abstract

Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spontaneous preterm delivery, meconium staining of the amniotic fluid, and stillbirth. It is commonly treated with ursodeoxycholic acid. There is accumulating evidence to suggest that intrahepatic cholestasis of pregnancy has a lasting influence on both maternal and fetal health. We review the etiology, diagnosis, and management of this intriguing condition.

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Comment in

  • Intrahepatic cholestasis of pregnancy.
    Henderson CE, Rezai S, Julien SA, Gottimukkala S. Henderson CE, et al. Obstet Gynecol. 2014 Dec;124(6):1210. doi: 10.1097/AOG.0000000000000571. Obstet Gynecol. 2014. PMID: 25411748 No abstract available.
  • In reply.
    Williamson C, Geenes V. Williamson C, et al. Obstet Gynecol. 2014 Dec;124(6):1210-1211. doi: 10.1097/AOG.0000000000000572. Obstet Gynecol. 2014. PMID: 25411749 No abstract available.

References

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    1. Kenyon AP, Piercy CN, Girling J, Williamson C, Tribe RM, Shennan AH. Obstetric cholestasis, outcome with active management: a series of 70 cases. BJOG 2002;109:282–8.
    1. Laatikainen T, Ikonen E. Fetal prognosis in obstetric hepatosis. Ann Chir Gynaecol Fenn 1975;64:155–64.
    1. Laatikainen T, Tulenheimo A. Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy. Int J Gynaecol Obstet 1984;22:91–4.

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