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Comment
. 2014 Jun;20(6):583-5.
doi: 10.1038/nm.3598.

Lessons from babies: inducing HIV-1 broadly neutralizing antibodies

Georgia D Tomaras  1 , Barton F Haynes  2
Affiliations
Comment

Lessons from babies: inducing HIV-1 broadly neutralizing antibodies

Georgia D Tomaras et al. Nat Med. 2014 Jun.

Abstract

A new study in infants shows that broadly neutralizing antibodies (bNAbs) against HIV can be found early in life, demonstrating for the first time that these antibodies can be induced by the infant immune system.

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Conflict of interest statement

Competing financial interests

B.F.H. has the following patent applications relating to HIV-1 vaccine immunogen design: “Antibody Evolution Immunogens,” “Swarm Immunization with Envelopes from CH505,” “B Cell Lineage Design,” “Synthetic Env Proteins” and “Polyvalent Vaccine.”

Figures

Figure 1
Figure 1. Timing and class of bNAbs induced in HIV-1–infected infants
Initially after HIV transmission, there is limited or no de novo antibody neutralization of heterologous viruses; instead, antibody responses seem to be predominantly restricted to neutralization of maternally transmitted virus. Goo et al. now show that the infant antibody response can mature over time early in life to broadly neutralize multiple HIV-1 clades, demonstrating the infant B cell repertoire is capable of responding to HIV-1 antigens and generating cross-reactive neutralizing antibodies. Kim Caesar/Nature Publishing Group
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Comment on

References

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