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Case Reports
. 2014 Apr;36(2):117-9.

Osseous metaplasia within a urothelial bladder cancer nodal metastasis: a case report

Luigi Cormio, Francesca Sanguedolce, Paolo Massenio, Giuseppe Di Fino, Oscar Selvaggio, Pantaleo Bufo, Giuseppe Carrieri
  • PMID: 24902364
Case Reports

Osseous metaplasia within a urothelial bladder cancer nodal metastasis: a case report

Luigi Cormio et al. Anal Quant Cytopathol Histpathol. 2014 Apr.

Abstract

Background: Osseous metaplasia within bladder cancer is extremely rare and, to our knowledge, has not been previously reported within a urothelial bladder carcinoma (UBC) nodal metastasis.

Case: A 78-year-old man underwent radical cystoprostatectomy because of high-grade pT2 UBC. Pathology revealed a high-grade pT4aN2 UBC with osseous metaplasia into a massively metastatic lymph node but not into the primary bladder tumor.

Conclusion: Based independently on its location, this finding warrants a careful differential diagnosis with sarcomatoid bladder tumors and is likely to be a marker of tumor aggressiveness, thus recommending aggressive treatment.

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