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Review
. 2014 May 19:4:113.
doi: 10.3389/fonc.2014.00113. eCollection 2014.

MicroRNA Machinery Genes as Novel Biomarkers for Cancer

Jing-Tao Huang  1 , Jin Wang  2 , Vibhuti Srivastava  2 , Subrata Sen  2 , Song-Mei Liu  1
Affiliations
Review

MicroRNA Machinery Genes as Novel Biomarkers for Cancer

Jing-Tao Huang et al. Front Oncol. .

Abstract

MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.

Keywords: alterations; biomarker; cancer; machinery genes; miRNA.

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Figures

Figure 1
Figure 1
Structure of microRNA machinery genes and miRNA biosynthesis.
See this image and copyright information in PMC

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