Competitive endogenous RNAs cannot alter microRNA function in vivo
- PMID: 24905003
- DOI: 10.1016/j.molcel.2014.05.023
Competitive endogenous RNAs cannot alter microRNA function in vivo
Abstract
In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.Mol Cell. 2014 Jun 5;54(5):766-76. doi: 10.1016/j.molcel.2014.03.045. Epub 2014 May 1. Mol Cell. 2014. PMID: 24793693 Free PMC article.
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