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Comment
. 2014 Jun 5;14(6):704-5.
doi: 10.1016/j.stem.2014.05.016.

Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging

Christopher Hine  1 , James R Mitchell  2
Affiliations
Comment

Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging

Christopher Hine et al. Cell Stem Cell. .

Abstract

Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.

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Figures

Figure 1
Figure 1
Prolonged Fasting Boosts Bone Marrow HSC Self-Renewal and Increases Resistance to Chemotherapeutic Toxicity and Aging-Related Loss of Homeostasis through Decreased IGF-1/PKA Signaling This results in maintenance of lymphoid cell (LC) and myeloid cell (MC) numbers and ratios and improved immune function.
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