doi: 10.1016/0731-7085(89)80153-0.
Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B
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- PMID: 2490531
- DOI: 10.1016/0731-7085(89)80153-0
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Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B
J Pharm Biomed Anal.
1989.
Abstract
A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.
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